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Premiered on CBS in September 2003, the series has become the most popular sitcom in America.As of the 2010–2011 season, Two and a Half Men would have completed eight seasons.In February 2011, however, CBS canceled the production of the rest of the eighth season, following several incidents of production shutdowns allegedly due to Charlie Sheen's problems with substance abuse, the last of which culminated in Sheen's verbal attacks directed at Lorre in a radio interview.

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Each episode usually focuses on the daily lives of the men and two of their equally nerdy friends, with a dose of absurdity from the relationship with their normal neighbor.

The two main protagonists, Sheldon and Leonard, are named after the actor and television producer Sheldon Leonard.

At the end of every episode of Dharma & Greg, Two and a Half Men, The Big Bang Theory and Mike & Molly, Lorre features a vanity card consisting of a message that usually reads like an editorial, essay, or observation on life.

) is a writer, director, producer and composer who has created many American sitcoms, including Grace Under Fire, Cybill, Dharma & Greg, Two and a Half Men, Mom and The Big Bang Theory.

Chuck also serves as executive producer of the sitcom Mike & Molly which premiered in September 2010.

It premiered on ABC in 1993, and was nominated at the 52nd Golden Globe Awards for Best Television Series – Musical or Comedy. The show aired for four seasons on CBS and received critical acclaim, winning an Emmy in 1995: Best Supporting Actress in a Comedy series for co-star Christine Baranski and 2 Golden Globe Awards in 1996: Best TV series (Musical or Comedy) and Best Actress in a TV series (Musical or Comedy).Lorre's next project, Dharma and Greg, was conceived in 1997, one year before the end of Cybill.The show starred Jenna Elfman and Thomas Gibson as the title characters.In 2003, Lorre co-created Two and a Half Men with Lee Aronsohn.The show focuses on two brothers, one of whom, Charlie (Charlie Sheen), is a rich, successful womanizer who owns a beach house at Malibu.His brother Alan (Jon Cryer) gets a divorce and is forced to move into his brother's Malibu house. Jones) the "half" who comes to visit the brothers on weekends.

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